vasopressin receptors การใช้

• The V1a vasopressin receptor gene is a mechanism most widely studied.
• Conivaptan inhibits two of the three subtypes of the vasopressin receptor ( V2 ).
• Studies have also found that testosterone facilitates aggression by modulating vasopressin receptors in the hypothalamus.
• This increase correlates with increase in vasopressin receptors in this area of the paternal brain.
• Polygamous Voles have a significantly smaller number of vasopressin receptors and remain shy even after mating.
• Felypressin is a Vasopressin 1 agonist, and will thus have effects at all Arginine vasopressin receptor 1As.
• AVPR1B was initially described as a novel vasopressin receptor located in the anterior pituitary, where it stimulates ACTH release.
• Emory researchers noted the genetically altered mice developed vasopressin receptors in the same parts of the brain as in prairie voles.
• Synthetic aquaretics are vasopressin receptor antagonists, such conivaptan, tolvaptan, demeclocycline and OPC-31260, as well as lithium.
• Therefore, it is alteration of vasopressin receptor gene expression patterns is thought to affect social behavior, rather than the neuropeptide itself.
• Monogamous voles, such as prairie voles, have significantly greater density and distribution of vasopressin receptors in their brain when compared to polygamous voles.
• However, in theory, vasopressin receptor antagonism would be particularly useful in this setting, and an initial study shows that it has some promise.
• No head-to-head study is currently available to quantify and compare the relative efficacies of V2 vasopressin receptor antagonists with demeclocycline or other treatment options.
• Demeclocycline has since been the drug of choice for treating SIADH, although it may be superseded as vasopressin receptor antagonists, such as tolvaptan, become available.
• Oxytocin and vasopressin receptors are present in many other brain regions, including the amygdala, brainstem, and septum, as well as most nuclei in the hypothalamus.
• Retosiban has high affinity for the oxytocin receptor ( K i = 0.65 nM ) and has greater than 1400-fold selectivity over the related vasopressin receptors
• As noted above, different species of voles vary in their sexual behavior, and these differences correlate with expression levels of vasopressin receptors in reward areas of the brain.
• Several selective ligands for the oxytocin receptor have recently been developed, but close similarity between the oxytocin and related vasopressin receptors make it difficult to achieve high selectivity with peptide derivatives.
• Scientists were able to change adult male montane voles'behavior to resemble that of monogamous prairie voles in experiments in which vasopressin receptors were introduced into the brain of male montane voles.
• Vasopressin receptors distributed along the reward circuit pathway, to be specific in the ventral pallidum, are activated when AVP is released during social interactions such as mating, in monogamous prairie voles.